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It has been marketed to boost weight loss, increase metabolism and also improve memory. It’s chemical orientation means that it may offer some of the benefits of DHEA but without the direct influence on steroid sex hormones. It is listed under anabolic steroids, most probably due to it’s relation to testosterone-stimulating DHEA .
Sunderland T, Merril CR, Harrington MG, et al. Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Buvat J. Androgen therapy with dehydroepiandrosterone. Rowland NE, Marshall M, Robertson K. Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine.
And Mecocci, P. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. Stanczyk, F. Z., Slater, C. C., Ramos, D. E., Azen, C., Cherala, G., Hakala, C., Abraham, G., and Roy, S. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women. Barad, D., Brill, H., and Gleicher, N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. And Holloszy, J. O. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Fukui, M., Kitagawa, Y., Nakamura, N., Kadono, M., Yoshida, M., Hirata, C., Wada, K., Hasegawa, G., and Yoshikawa, T. Serum dehydroepiandrosterone sulfate concentration and carotid atherosclerosis in men with type 2 diabetes. Dhatariya, K., Bigelow, M. L., and Nair, K. S. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women.
In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors. As the metabolism of testosterone in males is more pronounced, the daily production is about 20 times greater in men. In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. The ability of 7-KETO, a substance related to DHEA, to promote weight loss in overweight people has been investigated in one double-blind trial.1 Participants in the trial were advised to exercise three times per week for 45 minutes and to eat an 1,800-calorie-per-day diet. Some dieters say that 7-KETO helps promote weight loss, when used along with a diet and exercise program.
Loria, R. M., Inge, T. H., Cook, S. S., Szakal, A. K., and Regelson, W. Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA). Gonzalez, F., Nair, K. S., Daniels, J. K., Basal, E., and Schimke, J. M. Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Traish, A. M., Kang, H. P., Saad, F., and Guay, A. T. Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology. Gomez-Santos, C., Larque, E., Granero, E., Hernandez-Morante, J. J., and Garaulet, M. Dehydroepiandrosterone-sulphate replacement improves the human plasma fatty acid profile in plasma of obese women. May, M., Holmes, E., Rogers, W., and Poth, M. Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone. Patte-Mensah, C., Meyer, L., Kibaly, C., and Mensah-Nyagan, A. G. Regulatory effect of dehydroepiandrosterone on spinal cord nociceptive function.
Certain cytochrome P450 enzymes such as CYP2C9 and CYP2C19 can also oxidize testosterone at the C17 position to form androstenedione. In addition to 6β- and 16β-hydroxytestosterone, 1β-, 2α/β-, 11β-, and 15β-hydroxytestosterone are also formed as minor metabolites. The 6β-hydroxylation of testosterone is catalyzed mainly by CYP3A4 and to a lesser extent CYP3A5 and is responsible for 75 to 80% of cytochrome P450-mediated testosterone metabolism. A small portion of approximately 3% of testosterone is reversibly converted in the liver into androstenedione by 17β-HSD. The conjugates of testosterone and its hepatic metabolites are released from the liver into circulation and excreted in the urine and bile.. Gynecomastia produced by dehydroepiandrosterone excess.|A typical dose of 2–3 grams daily can yield noticeable benefits in men over 40 with declining testosterone, but it may be less effective in younger populations. Another popular contender, D-aspartic acid (DAA), works by increasing follicle-stimulating hormone (FSH) and LH, which in turn can elevate testosterone. In contrast, supplements like Tribulus terrestris and fenugreek operate through direct hormonal pathways, often stimulating luteinizing hormone (LH) to increase testosterone synthesis. Regular blood tests to monitor hormone levels are essential to ensure the dosage remains appropriate and to adjust as needed. A typical starting point for women is 25 mg daily, with careful monitoring to avoid virilization effects. However, younger adults should exercise caution, as their bodies are already producing optimal hormone levels. For individuals over 40, who may experience natural testosterone decline, doses up to 100 mg daily have been studied with promising results.|Leal, A. M., Magalhaes, P. K., Souza, C. S., and Foss, N. T. Adrenocortical hormones and interleukin patterns in leprosy. Tagliaferro, A. R., Roebuck, B. D., Ronan, A. M., and Meeker, L. D. Enhancement of pancreatic carcinogenesis by dehydroepiandrosterone. ROBERTS, K. D., VANDEWIELE, R. L., and Lieberman, S. The conversion in vivo of dehydroisoandrosterone sulfate to androsterone and etiocholanolone glucuronidates.|Van Weering, H. G., Gutknecht, D. R., and Schats, R. Augmentation of ovarian response by dehydroepiandrosterone. Murialdo, G., Barreca, A., Nobili, F., Rollero, A., Timossi, G., Gianelli, M. V., Copello, F., Rodriguez, G., and Polleri, A. Relationships between cortisol, dehydroepiandrosterone sulphate and insulin-like growth factor-I system in dementia. Sulcova, J., Hill, M., Hampl, R., Masek, Z., Novacek, A., Ceska, R., and Starka, L. Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men. Does dehydroepiandrosterone improve well-being? Lee, K. S., Oh, K. Y., and Kim, B. C. Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture. Elekima, O. T., Mills, C. O., Ahmad, A., Skinner, G. R., Ramsden, D. B., Bown, J., Young, T. W., and Elias, E. Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.7-Keto DHEA, a metabolite of DHEA (dehydroepiandrosterone), has garnered attention for its potential role in influencing testosterone production. Effects of lifelong testosterone exposure on health and disease using Mendelian randomization. Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people. ASI testing evaluates cortisol levels throughout the day, offering insights into how well the adrenal glands are functioning.Panjari, M., Bell, R. J., Jane, F., Wolfe, R., Adams, J., Morrow, C., Davis, S. R. A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. Gebre-Medhin, G., Husebye, E. S., Mallmin, H., Helstrom, L., Berne, C., Karlsson, F. A., Kampe, O. Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. Finckh, A., Berner, I. C., Aubry-Rozier, B., So, A. K. A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia. Nordmark, G., Bengtsson, C., Larsson, A., Karlsson, F. A., Sturfelt, G., Ronnblom, L. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study. Aisaka, K., Mori, H., Ogawa, T., Kigawa, T. Effects of dehydroepiandrosterone-sulphate (DHEA-S) administration on puerperal lactation and maternal prolactin and estradiol levels.At the tissue level, testosterone dissociates from albumin and quickly diffuses into the tissues. This binding plays an important role in regulating the transport, tissue delivery, bioactivity, and metabolism of testosterone. Only the free amount of testosterone can bind to an androgenic receptor, which means it has biological activity.For men over 35 experiencing mild testosterone decline, it can be a valuable adjunct to diet and exercise. Monitoring hormone levels through blood tests every 3–6 months is recommended to ensure optimal outcomes. Additionally, it enhances thyroid function, which indirectly supports testosterone production by improving overall metabolic efficiency. Elevated cortisol levels are known to suppress testosterone production by interfering with the hypothalamic-pituitary-gonadal (HPG) axis. To understand its mechanism, it’s essential to examine how it interacts with the body’s endocrine system and metabolic pathways. Unlike DHEA, 7-Keto DHEA does not convert into sex hormones like testosterone or estrogen, which makes its mechanism of action distinct.
Araneo, B. A., Shelby, J., Li, G. Z., Ku, W., and Daynes, R. A. Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence. De la, Torre B., Hedman, M., Nilsson, E., Olesen, O., and Thorner, A. Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis. Wisniewski, T. L., Hilton, C. W., Morse, E. V., and Svec, F. The relationship of serum DHEA-S and cortisol levels to measures of immune function in human immunodeficiency virus-related illness. Hautanen, A., Manttari, M., Manninen, V., Tenkanen, L., Huttunen, J. K., Frick, M. H., and Adlercreutz, H. Adrenal androgens and testosterone as coronary risk factors in the Helsinki Heart Study. Yang, J. Y., Schwartz, A., and Henderson, E. E. Inhibition of HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and an analog of DHEA.
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